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Evaluation of Epidermal Growth Factor-Incorporating Skin Care Product in Culture Experiment Using Human Fibroblasts

A Yamamoto, H Ohno, Y Kuroyanagi – Open Journal of Regenerative Medicine, 2016

This study aimed to investigate the potential of a skin care product composed of hyaluronic acid (HA) and collagen (Col) sponge containing epidermal growth factor (EGF), vitamin C derivative (VC), glucosylceramide (GC), poly (γ-glutamic acid)(PGA), and argentine (Arg). …

Transforming growth factor beta 1 increases collagen content, and stimulates procollagen I and tissue inhibitor of metalloproteinase-1 production of dental pulp cells:

PS Lin, HH Chang, CY Yeh, MC Chang, CP Chan… – Journal of the Formosan …, 2016

Methods Pulp cells were exposed to TGF-β1 with/without pretreatment and coincubation by 1, 4-diamino-2, 3-dicyano-1, 4-bis (o-aminophenyl mercapto) butadiene (U0126; a mitogen-activated protein kinase kinase [MEK]/extracellular signal-regulated kinase [ERK] inhibitor …

Integration of Growth Factor Gene Delivery with Collagen‐Triggered Wound Repair Cascades using Collagen‐Mimetic Peptides

MA Urello, KL Kiick, MO Sullivan – Bioengineering & Translational Medicine, 2016

ABSTRACT Growth factors (GFs) play vital roles in wound repair. Many GF therapies have reached clinical trials, but success has been hindered by safety concerns and a lack of efficacy. Previously, we presented an approach to produce protein factors in wound beds …

… ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: A Prospective Study.

X Chen, M Al-Sheikh, CK Chan, AH Hariri, P Abraham… – RETINA, 2016

Purpose: To evaluate the response to aflibercept therapy for Type 1 and Type 3 neovascularization in pigment epithelial detachments associated with treatment-naive, neovascular age-related macular degeneration. Methods: In this multicentered, …

Shear stress magnitude and transforming growth factor-βeta 1 regulate endothelial to mesenchymal transformation in a three-dimensional culture microfluidic device

S Mina, W Wang, Q Cao, P Huang, BT Murray… – RSC Advances, 2016

Normal fibroblasts are present within the extracellular matrix (ECM). They can become activated, leading to increased proliferation and ECM protein secretion such as collagen type I to promote tissue remodeling. These cells are also involved in adult pathologies …

Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and …

H Masuki, T Okudera, T Watanebe, M Suzuki… – International Journal of …, 2016

Background The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF’s clinical effectiveness has often been …

Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration

RWD Gilbert, MK Vickaryous, AM Viloria-Petit – Journal of Developmental Biology, 2016

Abstract: Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms and downstream mediators of canonical and non-canonical signalling play …

Epidermal growth factor receptor inhibitors trigger a type I interferon response in human skin.

D Lulli, CM Luigia, S Pastore – Oncotarget, 2016

The Epidermal Growth Factor Receptor (EGFR) is centrally involved in the regulation of key processes of the epithelia, including cell proliferation, survival, differentiation, and also tumorigenesis. Humanized antibodies and small-molecule inhibitors targeting EGFR were …

FGF18 Signaling in the Hair Cycle Resting Phase Determines Radioresistance of Hair Follicles by Arresting Hair Cycling

M Kawano, S Umeda, T Yasuda, M Fujita, A Ishikawa… – Advances in Radiation …, 2016

… Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, while several other FGFs exert radioprotective effects. However, the
role of FGF18 in the radioresistance of HFs remains unknown. …